Development of a Large-Scale Synthetic Route to Manufacture (鈭?-Huperzine A

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• 作者：Stephen R. Tudhope ; Julie A. Bellamy ; Anthony Ball ; Dewakar Rajasekar ; Manouchehr Azadi-Ardakani ; Harihara Subramanian Meera ; Jesudoss Mercy Gnanadeepam ; Ramanathan Saiganesh ; Frank Gibson ; Linli He ; Carl H. Behrens ; Gail Underiner ; Judith Marfurt ; Nathalie Favre
• 刊名：Organic Process Research & Development
• 出版年：2012
• 出版时间：April 20, 2012
• 年：2012
• 卷：16
• 期：4
• 页码：635-642
• 全文大小：317K
• 年卷期：v.16,no.4(April 20, 2012)
• ISSN：1520-586X

文摘

A safe, practical and scalable process for manufacture of (鈭?-huperzine A has been developed and scaled up to manufacture several hundred grams of (鈭?-huperzine A with chemical and optical purity of >99%. The process consists of 11 chemical stages starting from commercially available materials with only nine isolation steps and no chromatography purification. This process provides a reliable and cost-effective source of synthetic (鈭?-huperzine A and its derivatives for pharmaceutical and nutraceutical markets.