Branching of poly(ADP-ribose): Synthesis of the Core Motif

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• 作者：Hans A. V. Kistemaker ; Herman S. Overkleeft ; Gijsbert A. van der Marel ; Dmitri V. Filippov
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：September 4, 2015
• 年：2015
• 卷：17
• 期：17
• 页码：4328-4331
• 全文大小：332K
• ISSN：1523-7052

文摘

The synthesis of the core motif of branched poly(adenosine diphosphate ribose) (poly(ADPr)) is described, and structural analysis reasserted the proposed stereochemistry for branching. For the synthesis, a ribose trisaccharide was first constructed with only 伪-O-glycosidic linkages. Finally, the adenine nucleobase was introduced via a Vorbr眉ggen-type glycosylation reaction. The orthogonality of the selected protecting groups was demonstrated, allowing for the construction of branched poly(ADPr) oligomers in the near future.