Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound
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- 作者：James B. Thomas ; Angela M. Giddings ; Robert W. Wiethe ; Srinivas Olepu ; Keith R. Warner ; Philippe Sarret ; Louis Gendron ; Jean-Michel Longpre ; Yanan Zhang ; Scott P. Runyon ; Brian P. Gilmour
- 刊名：Journal of Medicinal Chemistry
- 出版年：2014
- 出版时间：June 26, 2014
- 年：2014
- 卷：57
- 期：12
- 页码：5318-5332
- 全文大小：612K
- ISSN：1520-4804
文摘
Compounds active at neurotensin receptors (NTS1 and NTS2) exert analgesic effects on different types of nociceptive modalities, including thermal, mechanical, and chemical stimuli. The NTS2 preferring peptide JMV-431 (2) and the NTS2 selective nonpeptide compound levocabastine (6) have been shown to be effective in relieving the pain associated with peripheral neuropathies. With the aim of identifying novel nonpeptide compounds selective for NTS2, we examined analogues of SR48692 (5a) using a FLIPR calcium assay in CHO cells stably expressing rat NTS2. This led to the discovery of the NTS2 selective nonpeptide compound 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid (NTRC-739, 7b) starting from the nonselective compound 5a.