Fast and Clean Borylation of Aryl Halides Under Flow Using Sol鈥揋el Entrapped SiliaCat DPP-Pd

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• 作者：Valerica Pandarus ; Genevi猫ve Gingras ; Fran莽ois B茅land ; Rosaria Ciriminna ; Mario Pagliaro
• 刊名：Organic Process Research & Development
• 出版年：2014
• 出版时间：November 21, 2014
• 年：2014
• 卷：18
• 期：11
• 页码：1556-1559
• 全文大小：266K
• ISSN：1520-586X

文摘

The fast and clean synthesis of boronic acid pinacol esters starting from aryl halides and bis(pinacolato)diboron is heterogeneously carried out over the SiliaCat DPP-Pd solid catalyst with largely enhanced reaction rate and catalyst stability. This opens the route to the transfer of cross-coupling borylation in a flow microreactor from the research level to process development.