New Formulation of Functionalized Bioactive Glasses to Be Used as Carriers for the Development of pH-Stimuli Responsive Biomaterials for Bone Diseases

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• 作者：Valentina Aina ; Claudio Magistris ; Giuseppina Cerrato ; Gianmario Martra ; Guido Viscardi ; Gigliola Lusvardi ; Gianluca Malavasi ; Ledi Menabue
• 刊名：Langmuir
• 出版年：2014
• 出版时间：April 29, 2014
• 年：2014
• 卷：30
• 期：16
• 页码：4703-4715
• 全文大小：605K
• 年卷期：v.30,no.16(April 29, 2014)
• ISSN：1520-5827

文摘

The aim of the present contribution is to prepare a functionalized bioactive glass potentially useful as prosthetic material, but also able to release organic molecules in response to a change of the pH environment. By this approach it is possible to develop devices which can be used for a triggered drug release in response to specific stimuli; this is an attractive research field, in order to avoid either systemic and/or local toxic effects of drugs. In particular, in the present paper we report data related to the development of a new formulation of bioactive glasses, their functionalization with organic molecules to obtain a pH-sensitive bond, their physicochemical characterization and in vitro bioactivity in simulated biological fluids (SBF), and organic molecule delivery tests at different pH. The glass functionalization, by means of a covalent reaction, allows us to produce a model of pH-responsive bioactive biomaterial: when it is exposed to specific pH changes, it can favor the release of the organic molecules directly at the target site. Cysteamine and 5-aminofluorescein are used as model molecules to simulate a drug. The materials, before and after the different functionalization steps and in vitro release tests at different pH, have been characterized by means of different experimental techniques such as X-ray powder diffraction (XRPD), Raman, FTIR and fluorescence spectroscopies, N₂ adsorption, thermogravimetric (TGA) and elemental analysis.