Novel Terphenyls and 3,5-Diaryl Isoxazole Derivatives Endowed with Growth Supporting and Antiapoptotic Properties

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• 作者：Daniele Simoni ; Riccardo Rondanin ; Riccardo Baruchello ; Michele Rizzi ; Giuseppina Grisolia ; Marco Eleopra ; Stefania Grimaudo ; Antonietta Di Cristina ; Maria Rosaria Pipitone ; Maria Rita Bongiorno ; Mari
• 刊名：Journal of Medicinal Chemistry
• 出版年：2008
• 出版时间：August 14, 2008
• 年：2008
• 卷：51
• 期：15
• 页码：4796-4803
• 全文大小：188K
• 年卷期：v.51,no.15(August 14, 2008)
• ISSN：1520-4804

文摘

A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.