Antiproliferative Oleanane Saponins from Meryta denhamii
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- 作者：Giuseppina Cioffi ; Fabrizio Dal Piaz ; Antonio Vassallo ; Fabio Venturella ; Paolo De Caprariis ; Francesco De Simone ; Nunziatina De Tommasi
- 刊名：Journal of Natural Products
- 出版年：2008
- 出版时间：June 2008
- 年：2008
- 卷：71
- 期：6
- 页码：1000 - 1004
- 全文大小：90K
- 年卷期：v.71,no.6(June 2008)
- ISSN：1520-6025
文摘
Eight new oleanane saponins (1−8) together with four know saponins (9−12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.