Self-Duplicating Amplification in a Dynamic Combinatorial Library

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• 作者：Shengguang Xu ; Nicolas Giuseppone
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：February 13, 2008
• 年：2008
• 卷：130
• 期：6
• 页码：1826 - 1827
• 全文大小：96K
• 年卷期：v.130,no.6(February 13, 2008)
• ISSN：1520-5126

文摘

A dynamic combinatorial library has been designed to produce a set of constituents among which one is able to self-complementarily direct its duplication. The overall molecular distribution in the library evolves along both kinetic and thermodynamic biases, leading to the amplification of the species that reproduces most efficiently and to the depletion of the other competitors.