Adsorbent Screening Using Microplate Spectroscopy for Selective Removal of Colored Impurities from Active Pharmaceutical Intermediates

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• 作者：Christopher J. Welch ; William R. Leonard ; Derek W. Henderson ; Benjamin Dorner ; Karla Glaser Childers ; John Y. L. Chung ; Frederick W. Hartner ; Jennifer Albaneze-Walker ; Peter Sajonz
• 刊名：Organic Process Research & Development
• 出版年：2008
• 出版时间：January 2008
• 年：2008
• 卷：12
• 期：1
• 页码：81 - 87
• 全文大小：1741K
• 年卷期：v.12,no.1(January 2008)
• ISSN：1520-586X

文摘

A screening approach for identifying adsorbents and conditions for selective removal of colored impurities from solutions of pharmaceutical intermediates is described. In this method, a variety of process adsorbents are evaluated using a combination of HPLC or LC−MS and 96-well microplate UV–vis spectroscopy. Several representative examples are shown that illustrate the use of the technique for the selective removal of colored impurities from pharmaceutical development candidates or related intermediates.