Novel and Versatile Synthesis of Disubstituted 1,2-Dihydro-1,2,4-triazol-3-ones
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- 作者：Mark A. Graham ; Paul A. Bethel ; Jonathan Burgess ; Gary Fairley ; Steve C. Glossop ; Ryan D. R. Greenwood ; Clifford D. Jones ; Scott Lovell ; Steve Swallow
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：December 6, 2013
- 年：2013
- 卷：15
- 期：23
- 页码：6078-6081
- 全文大小：241K
- 年卷期：v.15,no.23(December 6, 2013)
- ISSN：1523-7052
文摘
A novel method for the synthesis of a wide range of 1,5-disubstituted 1,2-dihydro-1,2,4-triazol-3-ones is described. The key step involves a reaction between a dilithiated BOC-hydrazine and a N-alkoxycarbonylcarboximidothioate. A broad range of aryl and alkyl functional groups are tolerated, providing a versatile route for the synthesis of triazolones.