Process Development for Sodelglitazar: A PPAR Panagonist
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- 作者：Andrew D. Brown ; Roman D. Davis ; Russ N. Fitzgerald ; Bobby N. Glover ; Kim A. Harvey ; Lynda A. Jones ; Bing Liu* ; Daniel E. Patterson ; Matthew J. Sharp
- 刊名：Organic Process Research & Development
- 出版年：2009
- 出版时间：March 20, 2009
- 年：2009
- 卷：13
- 期：2
- 页码：297-302
- 全文大小：148K
- 年卷期：v.13,no.2(March 20, 2009)
- ISSN：1520-586X
文摘
Three efficient syntheses of sodelglitazar (1) have been developed. In particular, the third synthesis avoids the use of zinc and eliminates the resulting heavy metal waste stream as well as the potential genotoxic methanesulfonate in the two earlier syntheses. This process produces sodelglitazar in 74% overall yield from readily available thiophenol (8) and thiazole alcohol (3).