Discovery and Optimization of p38 Inhibitors via Computer-Assisted Drug Design
详细信息 查看全文
- 作者：Daniel R. Goldberg ; Ming-Hong Hao ; Kevin C. Qian ; Alan D. Swinamer ; Donghong A. Gao ; Zhaoming Xiong ; Chris Sarko ; Angela Berry ; John Lord ; Ronald L. Magolda ; Tazmeen Fadra ; Rachel R. Kroe ; Alison Kuk
- 刊名：Journal of Medicinal Chemistry
- 出版年：2007
- 出版时间：August 23, 2007
- 年：2007
- 卷：50
- 期：17
- 页码：4016 - 4026
- 全文大小：304K
- 年卷期：v.50,no.17(August 23, 2007)
- ISSN：1520-4804
文摘
Integration of computational methods, X-ray crystallography, and structure-activity relationships will bedisclosed, which lead to a new class of p38 inhibitors that bind to p38 MAP kinase in a Phe out conformation.