Mechanism for Polymorphic Transformation of Artemisinin during High Temperature Extrusion

详细信息    查看全文

• 作者：Chaitrali Kulkarni ; Adrian Kelly ; John Kendrick ; Tim Gough ; Anant Paradkar
• 刊名：Crystal Growth & Design
• 出版年：2013
• 出版时间：December 4, 2013
• 年：2013
• 卷：13
• 期：12
• 页码：5157-5161
• 全文大小：378K
• 年卷期：v.13,no.12(December 4, 2013)
• ISSN：1528-7505

文摘

A novel, green, and continuous method for solid-state polymorphic transformation of artemisinin by high temperature extrusion has recently been demonstrated. This communication describes attempts to understand the mechanisms causing phase transformation during the extrusion process. Polymorphic transformation was investigated using hot stage microscopy and a model shear cell. At high temperature, phase transformation from orthorhombic to the triclinic crystals was observed through a vapor phase. Under mechanical stress, the crystalline structure was disrupted continuously, exposing new surfaces and accelerating the transformation process.