Structure and Function of Cu(I)- and Zn(II)-ATPases

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• 作者：Oleg Sitsel ; Christina Gr酶nberg ; Henriette Elisabeth Autzen ; Kaituo Wang ; Gabriele Meloni ; Poul Nissen ; Pontus Gourdon
• 刊名：Biochemistry
• 出版年：2015
• 出版时间：September 22, 2015
• 年：2015
• 卷：54
• 期：37
• 页码：5673-5683
• 全文大小：578K
• ISSN：1520-4995

文摘

Copper and zinc are micronutrients essential for the function of many enzymes while also being toxic at elevated concentrations. Cu(I)- and Zn(II)-transporting P-type ATPases of subclass 1B are of key importance for the homeostasis of these transition metals, allowing ion transport across cellular membranes at the expense of ATP. Recent biochemical studies and crystal structures have significantly improved our understanding of the transport mechanisms of these proteins, but many details about their structure and function remain elusive. Here we compare the Cu(I)- and Zn(II)-ATPases, scrutinizing the molecular differences that allow transport of these two distinct metal types, and discuss possible future directions of research in the field.