Strategy in Oligosaccharide Synthesis: An Application to a Concise Total Synthesis of the KH-1(adenocarcinoma) Antigen
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- 作者：Prashant P. Deshpande ; Hyunjin M. Kim ; Andrzej Zatorski ; Tae-Kyo Park ; Govindaswami Ragupathi ; Philip O. Livingston ; David Live ; and Samuel J. Danishefsky
- 刊名：Journal of the American Chemical Society
- 出版年：1998
- 出版时间：February 25, 1998
- 年：1998
- 卷：120
- 期：7
- 页码：1600 - 1614
- 全文大小：211K
- 年卷期：v.120,no.7(February 25, 1998)
- ISSN：1520-5126
文摘
A concise and potentially practical synthesis of thetitle compound has been achieved. The routefeatures a high degree of convergence and economy of syntheticoperations. A key step is the concurrentintroductory addition of three 
-L-fucosyl residues atrequired hydroxyl acceptor sites (see 37 
39).Conjugation to carrier protein was achieved, and a route toinclude truncated structures for investigations forantibody specificity was accomplished.
-L-fucosyl residues atrequired hydroxyl acceptor sites (see 37 39).Conjugation to carrier protein was achieved, and a route toinclude truncated structures for investigations forantibody specificity was accomplished.