Synthesis of NanoQ, a Copper-Based Contrast Agent for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus
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- 作者：Dipanjan Pan ; Shelton D. Caruthers ; Angana Senpan ; Ceren Yalaz ; Allen J. Stacy ; Grace Hu ; Jon N. Marsh ; Patrick J. Gaffney ; Samuel A. Wickline ; Gregory M. Lanza
- 刊名：Journal of the American Chemical Society
- 出版年：2011
- 出版时间：June 22, 2011
- 年：2011
- 卷：133
- 期：24
- 页码：9168-9171
- 全文大小：767K
- 年卷期：v.133,no.24(June 22, 2011)
- ISSN：1520-5126
文摘
A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.