Rutile Promoted Synthesis of Sulfonylamidonitriles from Simple Aldehydes and Sulfonamides

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• 作者：Nicholas V. Costantini ; Alex D. Bates ; Graham J. Haun ; Natasha M. Chang ; Gustavo Moura-Letts
• 刊名：ACS Sustainable Chemistry & Engineering
• 出版年：2016
• 出版时间：April 4, 2016
• 年：2016
• 卷：4
• 期：4
• 页码：1906-1911
• 全文大小：384K
• ISSN：2168-0485

文摘

We report the first rutile-promoted synthesis of sulfonylamidonitriles from aldehydes and sulfonamides with NaCN in water. This transformation has proven to work for a variety of aliphatic and aromatic aldehydes with excellent yields. The scope also extends to a variety of substituted sulfonamides. Rutile can be easily recycled and reused without significant reaction erosion. The benign nature of rutile and its natural abundance highlights this transformation as a model green reaction.