Carbonyl-Twisted 6-Acyl-2-dialkylaminonaphthalenes as Solvent Acidity Sensors

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• 作者：Amy M. Green ; Hannah R. Naughton ; Zachariah B. Nealy ; Robert D. Pike ; Christopher J. Abelt
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：March 1, 2013
• 年：2013
• 卷：78
• 期：5
• 页码：1784-1789
• 全文大小：298K
• 年卷期：v.78,no.5(March 1, 2013)
• ISSN：1520-6904

文摘

Derivatives of 2-propionyl-6-dimethylaminonaphthalene (PRODAN) with twisted carbonyl groups were investigated as highly responsive sensors of H-bond donating ability. The PRODAN derivative bearing a pivaloyl group (4) was prepared. The torsion angle between the carbonyl and naphthalene is 26掳 in the crystal. It shows solvatochromism that is similar to five other PRODAN derivatives (1鈥?b>3, 5, 6). Twisted-carbonyl derivatives 3, 4, and 6 show strong fluorescence quenching in protic solvents. The order of magnitude of the quenching is linearly related to the H-bond donating ability of the solvent (SA) but not to other solvent properties. Binary mixtures of protic solvents show specific interaction effects with respect to quenching and solvatochromism. Aggregation in water is an issue with the pivaloyl derivatives.