文摘
Date (Phoenix dactylifera L.) fruit soluble phenolics composition and anti-atherogenic properties were examined in nine diverse Israeli grown varieties. Ethanol and acetone extracts of 鈥楢mari鈥? 鈥楤arhi鈥? 鈥楧eglet Noor鈥? 鈥楧eri鈥? 鈥楬adrawi鈥? 鈥楬allawi鈥? 鈥楬ayani鈥? 鈥楳edjool鈥? and 鈥榋ahidi鈥?fruit were analyzed for phenolics composition by RP-HPLC and tested for anti-atherogenicity by measuring their effects on LDL susceptibility to copper ion- and free radical-induced oxidation, and on serum-mediated cholesterol efflux from macrophages. The most frequently detected phenolics were hydroxybenzoates, hydroxycinnamates, and flavonols. Significant differences in phenolics composition were established between varieties as well as extraction solvents. All extracts inhibited LDL oxidation, and most extracts also stimulated cholesterol removal from macrophages. Considerable varietal differences were measured in the levels of the bioactivities. Also, acetone extracts exhibited a significantly higher anti-atherogenic potency for most varieties. The presence of soluble ingredients with anti-atherogenic capacities in dates and the possible involvement of phenolics are discussed.
Keywords:
anti-atherogenicity; antioxidants; cholesterol removal; date fruit; LDL oxidation; phenolics; Phoenix dactylifera L