Chemical Detoxification of Small Molecules by Caenorhabditis elegans

详细信息    查看全文

• 作者：Gregory S. Stupp ; Stephan H. von Reuss ; Yevgeniy Izrayelit ; Ramadan Ajredini ; Frank C. Schroeder ; Arthur S. Edison
• 刊名：ACS Chemical Biology
• 出版年：2013
• 出版时间：February 15, 2013
• 年：2013
• 卷：8
• 期：2
• 页码：309-313
• 全文大小：281K
• 年卷期：v.8,no.2(February 15, 2013)
• ISSN：1554-8937

文摘

Caenorhabditis elegans lives in compost and decaying fruit, eats bacteria and is exposed to pathogenic microbes. We show that C. elegans is able to modify diverse microbial small-molecule toxins via both O- and N-glucosylation as well as unusual 3鈥?O-phosphorylation of the resulting glucosides. The resulting glucosylated derivatives have significantly reduced toxicity to C. elegans, suggesting that these chemical modifications represent a general mechanism for worms to detoxify their environments.