A Practical Method for Preparation of 4-Hydroxyquinolinone Esters

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• 作者：Gregory L. Beutner ; Jeffrey T. Kuethe ; Nobuyoshi Yasuda
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：August 31, 2007
• 年：2007
• 卷：72
• 期：18
• 页码：7058 - 7061
• 全文大小：115K
• 年卷期：v.72,no.18(August 31, 2007)
• ISSN：1520-6904

文摘

4-Hydroxyquinolinone esters are a common motif for manymedicinal agents. Several methods exist for preparation ofthese compounds, generally involving the use of sodiumhydride, which raises significant safety issues and limits theirapplication to large-scale synthesis. In this note a practical,safe, and general method that employs a combination ofdiisopropylethylamine and sodium tert-butoxide is described.This allows for the synthesis of 4-hydroxyquinolinone estersand amides in good yields.