Ruthenium-Catalyzed Hydrogenation of Nitriles: Insights into the Mechanism
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- 作者：Rebeca Reguillo ; Mary Grellier ; Nicolas Vautravers ; Laure Vendier ; Sylviane Sabo-Etienne
- 刊名：Journal of the American Chemical Society
- 出版年：2010
- 出版时间：June 16, 2010
- 年：2010
- 卷：132
- 期：23
- 页码：7854-7855
- 全文大小：131K
- 年卷期：v.132,no.23(June 16, 2010)
- ISSN：1520-5126
文摘
Hydrogenation of benzonitrile into benzylamine is catalyzed under very mild conditions by the ruthenium bis(dihydrogen) complex RuH2(H2)2(PCyp3)2, incorporating two tricyclopentylphosphines. Two key intermediates have been isolated, resulting from the activation of benzonitrile at early stages of activation, i.e., either N-coordination through the nitrile function or first hydrogenation with benzylimine formation, followed by, thanks to C−H activation, coordination at ruthenium as an orthometalated ligand.