The surface preparation and photosensitization of highly oriented natural and synthetic SnO2 single crystals is investigated for the first time. Incident photon conversion efficiency (IPCE) spectra for SnO2 single crystals sensitized with both CdSe quantum dots (QD) and the thiacyanine dye are measured and interpreted. We discuss the influence of crystal face and doping density on the IPCE spectral response and magnitude. Advantages of SnO2 as a substrate for sensitization studies are also pointed out.