Stereoselective Alkene Isomerization over One Position
详细信息 查看全文
- 作者：Casey R. Larsen ; Douglas B. Grotjahn
- 刊名：The Journal of the American Chemical Society
- 出版年：2012
- 出版时间：June 27, 2012
- 年：2012
- 卷：134
- 期：25
- 页码：10357-10360
- 全文大小：296K
- 年卷期：v.134,no.25(June 27, 2012)
- ISSN：1520-5126
文摘
Although controlling both the position of the double bond and E:Z selectivity in alkene isomerization is difficult, <b>1b> is a very efficient catalyst for selective mono-isomerization of a variety of multifunctional alkenes to afford >99.5% E-products. Many reactions are complete within 10 min at room temperature. Even sensitive enols and enamides susceptible to further reaction can be generated. Catalyst loadings in the 0.01鈥?.1 mol% range can be employed. E-to-Z isomerization of the product from diallyl ether was only <10鈥? times as fast as its formation, showing the extremely high kinetic selectivity of <b>1b>.