Chemo- and Enantioselective Addition and 尾-Hydrogen Transfer Reduction of Carbonyl Compounds with Diethylzinc Reagent in One Pot Catalyzed by a Single Chiral Organometallic Catalyst

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• 作者：Huayin Huang ; Hua Zong ; Guangling Bian ; Ling Song
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：December 18, 2015
• 年：2015
• 卷：80
• 期：24
• 页码：12614-12619
• 全文大小：460K
• ISSN：1520-6904

文摘

Using a single chiral phosphoramide鈥揨n(II) complex as the catalyst, the asymmetric 尾-H transfer reduction of aromatic 伪-trifluoromethyl ketones and enantioselective addition of aromatic aldehydes with Et₂Zn in one pot were successfully realized, affording the corresponding additive products of secondary alcohols in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee) and the reduction products of 伪-trifluoromethyl alcohols in good to excellent yields with up to 77% ee.