Structural Characterization of Kadcoccinin A: A Sesquiterpenoid with a Tricyclo[4.4.0.03,10]decane Scaffold from Kadsura coccinea
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- 作者：Zheng-Xi Hu ; Yi-Ming Shi ; Wei-Guang Wang ; Jian-Wei Tang ; Min Zhou ; Xue Du ; Yong-Hui Zhang ; Jian-Xin Pu ; Han-Dong Sun
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：May 6, 2016
- 年：2016
- 卷：18
- 期：9
- 页码：2284-2287
- 全文大小：339K
- 年卷期：0
- ISSN：1523-7052
文摘
Kadcoccinin A (1), a cage-like sesquiterpenoid possessing a tricyclo[4.4.0.03,10]decane scaffold, and the biosynthetically related kadcoccinin B (2) were isolated from the stems of Kadsura coccinea. Their structures and absolute configurations were determined from extensive spectroscopic analysis and quantum chemical calculations. Additionally, their cytotoxic and antifungal effects were initially evaluated, and a plausible biosynthetic pathway was proposed.