Ligand-accelerated Enantioselective Propargylation of Aldehydes via Allenylzinc Reagents

详细信息    查看全文

• 作者：Barry M. Trost ; Ming-Yu Ngai ; Guangbin Dong
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：April 15, 2011
• 年：2011
• 卷：13
• 期：8
• 页码：1900-1903
• 全文大小：719K
• 年卷期：v.13,no.8(April 15, 2011)
• ISSN：1523-7052

文摘

An enantioselective propargylation of aldehydes using an allenylzinc reagent generated in situ via a zinc鈭抜odine exchange reaction is described. The enantioselectivity is controlled by addition of a catalytic amount of readily accessible and highly tunable amino alcohol ligand L13. A wide range of aldehydes can be propargylated to afford valuable and versatile homopropargyl alcohols in good to excellent yields with high levels of enantiopurity.