文摘
Maternal exposure to dioxins and related compoundsbefore conception may affect the health of the fetus. Toidentify factors affecting dioxin body load in Hong Kong, in2002, total dioxin-like activity was estimated in 250individual milk samples at 2-6 weeks postpartum, from arepresentative group of primiparous mothers, aged 18-42 years (mean 29 ± 5 years), by a chemically activatedluciferase expression (CALUX) bioassay. Associationsbetween the CALUX-TEQ and 20 socio-demographic anddietary variables were examined separately in mothersyounger than 30 years (n = 114) and 30 years or older (n= 119), by multiple linear regression analysis. CALUX-TEQ (mean 14.5 ± 5.8 pg/g fat) significantly increased by 0.4-0.5 pg/g fat for every year of the mother's age. Mothersborn in Guangdong province of China had a significantlyhigher CALUX-TEQ. Higher seafood consumption (oldermothers; p = 0.07) and having a female baby (youngermothers; p = 0.002) were associated with a higher maternalCALUX-TEQ level. Age was the strongest factor affectinghuman dioxin levels in Hong Kong. Birthplace andresidence are important indicators of variations in exposureto environmental pollution in the Asia Pacific region.Temporal trends in body loads of dioxins remain to beestablished and continuous monitoring of dioxins in humansand foods is necessary as a precautionary approach toguide environmental control measures and prevent exposureto infants.