Novel Fe3O4@ZnO@mSiO2 Nanocarrier for Targeted Drug Delivery and Controllable Release with Microwave Irradiation

详细信息    查看全文

• 作者：Hongjin Qiu ; Bin Cui ; Guangming Li ; Jianhui Yang ; Hongxia Peng ; Yingsai Wang ; Nini Li ; Ruicheng Gao ; Zhuguo Chang ; Yaoyu Wang
• 刊名：Journal of Physical Chemistry C
• 出版年：2014
• 出版时间：July 10, 2014
• 年：2014
• 卷：118
• 期：27
• 页码：14929-14937
• 全文大小：520K
• ISSN：1932-7455

文摘

In this paper, we constructed a novel core鈥搒hell structured nanocarrier used as a drug carrier to investigate the storage and controllable release properties of the cancer chemotherapeutic drug etoposide (VP16). The new composite nanocomposite composed of a mesoporous silica shell with magnetic Fe₃O₄ core and ZnO interlayer with a core鈥搒hell structure was prepared by a simple process. The mesoporous nanocarrier possesses high surface area (643.9 m²/g), provides large accessible pore volume (0.32 cm³/g) for the adsorption of drug molecules, and has a high magnetization saturation value (56.8 emu/g) for drug targeting under foreign magnetic fields, and the ZnO interlayer acts as a good microwave absorber with excellent microwave thermal response property for microwave-triggered drug release (the VP16 release of over 85% under microwave discontinuous irradiation outclasses the 14% within 10 h only stirring release). This multifunctional system shows a good performance for targeting delivery and controllable release of anticancer drugs based on all the properties they possess.