Synthesis of Oxidant Prone Nanosilver To Develop H2O2 Responsive Drug Delivery System

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• 作者：Faheem Muhammad ; Aifei Wang ; Lu Miao ; Pengyuan Wang ; Qin Li ; Jia Liu ; Jianshi Du ; Guangshan Zhu
• 刊名：Langmuir
• 出版年：2015
• 出版时间：January 13, 2015
• 年：2015
• 卷：31
• 期：1
• 页码：514-521
• 全文大小：539K
• ISSN：1520-5827

文摘

Our immune system uses toxicity of hydrogen peroxide to kill off bacterial invaders. In this contribution, we intended to integrate ROS producing capability of immune system with oxidant-sensitive nature of antibacterial silver nanoparticles (Ag NPs) to develop an oxidant drug delivery system. Prior to execute this strategy, we have developed an efficient one-pot synthetic protocol to produce ultrasmall (5 nm), water-stable, and oxidant-prone Ag NPs. Notably, the yield of as-synthesized Ag NPs is 10-fold higher than standard citrate reduction route. The resulting therapeutically active and well-dispersed Ag NPs are used as nanolids to cap the drug loaded nanochannels of porous silica. Upon exposing to H₂O₂, dissolution-accompanied aggregation of Ag nanolids unleashes the encapsulated therapeutic entities from channels of nanocarrier. Combination of antibacterial and anti-inflammatory drugs in single nanocarriers can potentially augment the effectiveness of various therapies.