Cladosins A鈥揈, Hybrid Polyketides from a Deep-Sea-Derived Fungus, Cladosporium sphaerospermum

详细信息    查看全文

• 作者：Guangwei Wu ; Xinhua Sun ; Guihong Yu ; Wei Wang ; Tianjiao Zhu ; Qianqun Gu ; Dehai Li
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：February 28, 2014
• 年：2014
• 卷：77
• 期：2
• 页码：270-275
• 全文大小：328K
• 年卷期：v.77,no.2(February 28, 2014)
• ISSN：1520-6025

文摘

Five new fungal hybrid polyketides, cladosins A鈥揇 (1鈥?b>4), that contain a novel linear 6(3)-enamino-8,10-dihydroxy-tetraketide (1 and 2) or 6-enamino-7(8)-en-10-ol (3 and 4) moiety, as well as the biogenetically related cladosin E (5), were isolated from the deep-sea-derived fungus Cladosporium sphaerospermum 2005-01-E3. Their structures (1鈥?b>5) were elucidated through a combination of spectroscopic data, chemical conversion, and both Mosher鈥檚 and Marfey鈥檚 methods for stereochemical assignment. A plausible biogenetic pathway to 1鈥?b>5 is proposed. Cladosin C (3) possesses mild anti-influenza A H1N1 virus activity.