6-Deoxy-13-hydroxy-8,11-dione-dihydrogranaticin B, an Intermediate in Granaticin Biosynthesis, from Streptomyces sp. CPCC 200532
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- 作者：Bingya Jiang ; Shufen Li ; Wei Zhao ; Ting Li ; Lijie Zuo ; Yanni Nan ; Linzhuan Wu ; Hongyu Liu ; Liyan Yu ; Guangzhi Shan ; Limin Zuo
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：September 26, 2014
- 年：2014
- 卷：77
- 期：9
- 页码：2130-2133
- 全文大小：231K
- ISSN：1520-6025
文摘
A new granaticin analogue and its hydrolysis product were isolated from Streptomyces sp. CPCC 200532. Their structures were determined to be 6-deoxy-13-hydroxy-8,11-dione-dihydrogranaticins B (1) and A (2), respectively, by detailed analysis of spectroscopic data. Compound 1 was regarded as an intermediate in granaticin biosynthesis, as it was bioconvertable to granaticin B. Compared to granaticin B, 1 showed similar cytotoxicity against cancer cell line HCT116, but decreased cytotoxicity against cancer cell lines A549, HeLa, and HepG2. Compound 2 displayed lower cytotoxicity than 1 against all four cancer cell lines tested.