Synthesis and Antiviral Activities of Antofine Analogues with Different C-6 Substituent Groups
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- 作者：Meng Wu ; Guifang Han ; Ziwen Wang ; Yuxiu Liu ; Qingmin Wang
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2013
- 出版时间：February 6, 2013
- 年：2013
- 卷：61
- 期：5
- 页码：1030-1035
- 全文大小：278K
- 年卷期：v.61,no.5(February 6, 2013)
- ISSN：1520-5118
文摘
On the basis of previous structure鈥揳ctivity relationship (SAR) and antiviral mechanism studies, antofine analogues with different substituent groups at the C-6 position targeting tobacco mosaic virus (TMV) RNA were synthesized for the first time. The antofine analogues 1a鈥?b>8a and 1b鈥?b>9b were evaluated for their antiviral activity against TMV. The SAR study of antofine analogues is discussed. Most of the compounds were found to exhibit higher antiviral activity than commercial Ningnanmycin in vitro and in vivo. The groups with hydrogen donor or electron-withdrawing groups at the C-6 position were found to be favorable for antiviral activity.