Total Synthesis of Phenanthroindolizidine Alkaloids through an Amidyl Radical Cascade/Rearrangement Reaction

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• 作者：Guifang Han ; Yuxiu Liu ; Qingmin Wang
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：October 18, 2013
• 年：2013
• 卷：15
• 期：20
• 页码：5334-5337
• 全文大小：264K
• 年卷期：v.15,no.20(October 18, 2013)
• ISSN：1523-7052

文摘

A short and general synthesis of the phenanthroindolizidine alkaloids is reported, featuring an unusual amidyl radical 5-exo/5-exo/rearrangement cascade of a xanthate precursor. Second, using an amidyl radical 5-exo/6-endo cascade to synthesize a phenanthroindolizidine alkaloid exclusively has been developed through a small structural modification.