Gold-Catalyzed Intramolecular Indole/Alkyne Cyclization Cascades through a Heterolytic Fragmentation: 1,5-Indole Migration and Allenylation

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• 作者：Guijie Li ; Yuanhong Liu
• 刊名：Journal of Organic Chemistry
• 出版年：2010
• 出版时间：May 21, 2010
• 年：2010
• 卷：75
• 期：10
• 页码：3526-3528
• 全文大小：718K
• 年卷期：v.75,no.10(May 21, 2010)
• ISSN：1520-6904

文摘

Gold-catalyzed intramolecular reactions of 3-alkynyl-bearing indoles with diol groups lead to the formation of highly functionalized 3-allenylindoles with high efficiency. The reaction likely proceeds by a new gold-catalyzed cascade cyclization/heterolytic fragmentation/elimination reactions, which results in 1,5-indole migration and C-3 allenylation of indole moiety.