Synthesis of Multisubstituted Pyrroles from Doubly Activated Cyclopropanes Using an Iron-Mediated Oxidation Domino Reaction
详细信息 查看全文
- 作者：Zhiguo Zhang ; Wei Zhang ; Junlong Li ; Qingfeng Liu ; Tongxin Liu ; Guisheng Zhang
- 刊名：Journal of Organic Chemistry
- 出版年：2014
- 出版时间：November 21, 2014
- 年：2014
- 卷：79
- 期：22
- 页码：11226-11233
- 全文大小：468K
- ISSN：1520-6904
文摘
An alternative route has been developed for the construction of multisubstituted pyrrole derivatives from readily available, doubly activated cyclopropanes and anilines using an iron-mediated oxidation domino reaction (i.e., sequential ring-opening, cyclization, and dehydrogenation reactions). This reaction uses readily available reactants and is tolerant of a broad range of substrates, with the desired products being formed in good to excellent yields.