A Rhodamine-Based Fluorescent Probe Containing a Se-N Bond for Detecting Thiols and Its Application in Living Cells

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• 作者：Bo Tang ; Yanlong Xing ; Ping Li ; Ning Zhang ; Fabiao Yu ; Guiwen Yang
• 刊名：Journal of the American Chemical Society
• 出版年：2007
• 出版时间：September 26, 2007
• 年：2007
• 卷：129
• 期：38
• 页码：11666 - 11667
• 全文大小：131K
• 年卷期：v.129,no.38(September 26, 2007)
• ISSN：1520-5126

文摘

Here we report a new rhodamine-based fluorescent probe containing a selenium-nitrogen bond for detecting thiols based on the nucleophilic substitution of sulfhydryl. The probe was successfully applied to the imaging of thiols in both HL-7702 cells and HepG2 cells with high sensitivity and selectivity.