Rhodium(III) Catalyzed Carboamination of Alkenes Triggered by C–H Activation of N-Phenoxyacetamides under Redox-Neutral Conditions
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- 作者：Zhiyong Hu ; Xiaofeng Tong ; Guixia Liu
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：April 1, 2016
- 年：2016
- 卷：18
- 期：7
- 页码：1702-1705
- 全文大小：388K
- ISSN：1523-7052
文摘
N-Alkoxyacrylamides are coupled with N-phenoxyacetamides by RhIII catalysis through C–H functionalization and amido group transfer under external oxidant-free conditions, which affords acyclic alkene carboamination products in an atom-economical way. Mechanistic insight into this transformation indicates the amide group in N-alkoxyacrylamide plays a critical role in this C–C/C–N bond formation reaction. This methodology provides a highly efficient way to construct o-tyrosine derivatives under mild conditions.