Delitschiapyrone A, a Pyrone鈥揘aphthalenone Adduct Bearing a New Pentacyclic Ring System from the Leaf-Associated Fungus Delitschia sp. FL1581
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- 作者：Jian-Guang Luo ; Xiao-Bing Wang ; Ya-Ming Xu ; Jana M. U鈥橰en ; A. Elizabeth Arnold ; Ling-Yi Kong ; A. A. Leslie Gunatilaka
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：November 21, 2014
- 年：2014
- 卷：16
- 期：22
- 页码：5944-5947
- 全文大小：283K
- ISSN：1523-7052
文摘
Delitschiapyrone A (1), an 伪-pyrone鈥搉aphthalenone adduct with an unprecedented pentacyclic ring system, was isolated from a solid culture of the leaf-associated fungus Delitschia sp. FL1581. The structure of 1 was elucidated by spectroscopic analysis and X-ray crystallography, and its absolute configuration was defined by experimental and calculated ECD. Biosynthetically, the unique 6/6/5/7/6 pentacyclic core of 1 may be formed by an intermolecular Diels鈥揂lder-type addition of the precursors derived from (1鈥?i>R)-2鈥?3鈥?dihydropyrenocine C (2) and 6-ethyl-2,7-dimethoxyjuglone (3) found to co-occur with 1 in this fungus.