Interfacial Reaction-Driven Formation of Silica Carbonate Biomorphs with Subcellular Topographical Features and Their Biological Activity

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• 作者：Guocheng Wang ; Xiaobing Zhao ; Marco M枚ller ; Sergio E. Moya
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：October 28, 2015
• 年：2015
• 卷：7
• 期：42
• 页码：23412-23417
• 全文大小：482K
• ISSN：1944-8252

文摘

We report the interfacial reaction-driven formation of micro/nanostructured strontium carbonate (SrCO₃) biomorphs with subcellular topographical features on strontium zinc silicate (Sr₂ZnSi₂O₇) biomedical coatings and explore their potential use in bone tissue engineering. The resulting SrCO₃ crystals build a well-integrated scaffold surface that not only prevents burst release of ions from the coating but also presents nanotopographical features similar to cellular filopodia. The surface with biomorphic crystals enhances osteoblast adhesion, upregulates the alkaline phosphatase activity, and increases collagen production, highlighting the potential of the silica carbonate biomorphs for tissue regeneration.