Regio- and Stereoselective Synthesis of Novel Dispiropyrrolidine Bisoxindole Derivatives via Multicomponent Reactions

详细信息    查看全文

• 作者：Hai Liu ; Guolan Dou ; Daqing Shi
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2010
• 出版时间：March 8, 2010
• 年：2010
• 卷：12
• 期：2
• 页码：292-294
• 全文大小：112K
• 年卷期：v.12,no.2(March 8, 2010)
• ISSN：1520-4774

文摘

A convenient and efficient method for the synthesis of novel dispiropyrrolidine bisoxindole derivatives by 1,3-dipolar cycloaddition reaction of azomethine ylides has been developed. The synthesis was achieved by using a one-pot multicomponent procedure. The features of this procedure were characterized by the following: mild reaction conditions, high yields, high regio- and stereoselectivity, one-pot procedure, and operational simplicity.