Nitrogen-Containing Dihydro-尾-agarofuran Derivatives from Tripterygium wilfordii

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• 作者：Yinggang Luo ; Xiang Pu ; Guoyong Luo ; Min Zhou ; Qi Ye ; Yan Liu ; Jian Gu ; Huayi Qi ; Guoyou Li ; Guolin Zhang
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：July 25, 2014
• 年：2014
• 卷：77
• 期：7
• 页码：1650-1657
• 全文大小：455K
• ISSN：1520-6025

文摘

Thunder god vine, the dried roots of Tripterygium wilfordii, is a widely used traditional Chinese medicine. More than 200 bioactive complex natural products have been isolated from this herb. Inspired by the diversity of chemical structures and bioactivities of the components of this herb, the investigation to mine new chemical entities as potential drug leads led to the identification of 36 nitrogen-containing compounds. Among them, 18 new dihydro-尾-agarofuran alkaloids (tripterygiumines A鈭扡 (1鈭?2), M鈭扱 (22鈭?6), and R (33)) were identified from the spectroscopic data and chemical degradation studies. Tripterygiumine Q (26) exhibited immunosuppressive activity against human peripheral mononuclear cells with an IC₅₀ value of 8.67 渭M and showed no cytotoxicity, even at 100 渭M, indicating that 26 may represent a novel scaffold for the development of new immunosuppressants.