An Effective Method for the Construction of Esters Using Cs2CO3 as Oxygen Source

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• 作者：Lanhui Ren ; Lianyue Wang ; Ying Lv ; Guosong Li ; Shuang Gao
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：17
• 期：21
• 页码：5172-5175
• 全文大小：334K
• ISSN：1523-7052

文摘

An effective method for the construction of esters from acyl chloride and halohydrocarbon using Cs₂CO₃ as an oxygen source was achieved for the first time. The methodology has a wide scope of substrates and can be scaled up. The study of a preliminary reaction mechanism demonstrated that the O in the products comes from Cs₂CO₃ and this esterification proceeds through a free radical reaction. It was also found that CO₂ can also be used in this esterification reaction as an oxygen source.