Preparation of Liquid-Core Nanocapsules from Poly[(ethylene oxide)-co-glycidol] with Multiple Hydrophobic Linoleates at an Oil-Water Interface and Its Encapsulation of Pyrene

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• 作者：Yong Ren ; Guowei Wang ; Junlian Huang
• 刊名：Biomacromolecules
• 出版年：2007
• 出版时间：June 2007
• 年：2007
• 卷：8
• 期：6
• 页码：1873 - 1880
• 全文大小：232K
• 年卷期：v.8,no.6(June 2007)
• ISSN：1526-4602

文摘

A convenient approach is provided to prepare liquid-core nanocapsules by cross-linking an amphiphilic copolymerat an oil-water interface. The hydrophilic copolymer poly[(ethylene oxide)-co-glycidol] was prepared by anionicpolymerization of ethylene oxide and ethoxyethyl glycidyl ether first, then the hydroxyl groups on the backbonewere recovered after hydrolysis and partly modified by hydrophobic conjugated linoleic acid. The copolymerwith multiple linoleate pendants was absorbed at an oil-water interface and then cross-linked to form stablenanocapsules. The mean diameter of the nanocapsule was below 350 nm, and the size distribution was relativelynarrow (<0.2) at low concentrations of oil in acetone (<10 mg/mL). The particle size could be tuned easily byvariation of the emulsification conditions. The nanocapsule was stable in water for at least 5 months, and theshell maintained its integrity after removal of the oily core by solvent. Pyrene was encapsulated in thesenanocapsules, and a loading efficiency as high as 94% was measured by UV spectroscopy.