Silver鈥揨witterion Organic鈥揑norganic Nanocomposite with Antimicrobial and Antiadhesive Capabilities

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• 作者：Rong Hu ; Guozhu Li ; Yujiao Jiang ; Yi Zhang ; Ji-Jun Zou ; Li Wang ; Xiangwen Zhang
• 刊名：Langmuir
• 出版年：2013
• 出版时间：March 19, 2013
• 年：2013
• 卷：29
• 期：11
• 页码：3773-3779
• 全文大小：433K
• 年卷期：v.29,no.11(March 19, 2013)
• ISSN：1520-5827

文摘

In this work, we demonstrate a convenient, efficient, and environmentally benign strategy to achieving antimicrobial and antiadhesive purposes using a silver鈥搝witterion nanocomposite. The synthesis of the nanocomposite relies on loading zwitterionic polymer brushes with Ag⁺ precursor ions, followed by their in situ reduction to Ag nanoparticle by ultraviolet (UV) irradiation. Both poly(sulfobetaine methacrylate) (pSBMA) and poly(carboxybetaine methacrylate) (pCBMA) have been studied as matrices for the embedding of silver. Well-dispersed silver nanoparticles are embedded into pCBMA matrices. The obtained pCBMA鈥搒ilver hybrid (CB-Ag) is capable of killing bacteria upon contact and releasing dead bacteria under wet conditions. Results suggest the feasibility of using this nanocomposite system as a robust and reliable antimicrobial and antiadhesive platform for the prevention of microbial colonization.