Applications of C鈥揌 Functionalization Logic to Cyclobutane Synthesis

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• 作者：Will R. Gutekunst ; Phil S. Baran
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：March 21, 2014
• 年：2014
• 卷：79
• 期：6
• 页码：2430-2452
• 全文大小：1231K
• 年卷期：v.79,no.6(March 21, 2014)
• ISSN：1520-6904

文摘

The application of C鈥揌 functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C鈥揌 functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C鈥揌 functionalization of cyclobutanes.