Unprecedented Synthesis of Alkynylphosphine-boranes through Room-Temperature Oxidative Alkynylation

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• 作者：K茅vin Jouvin ; Romain Veillard ; C茅dric Theunissen ; Carole Alayrac ; Annie-Claude Gaumont ; Gwilherm Evano
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：September 6, 2013
• 年：2013
• 卷：15
• 期：17
• 页码：4592-4595
• 全文大小：284K
• 年卷期：v.15,no.17(September 6, 2013)
• ISSN：1523-7052

文摘

An original and user-friendly synthesis of alkynylphosphine-boranes, useful building blocks in organic synthesis, based on an oxidative P-alkynylation reaction with readily available copper acetylides is reported. The ability of a secondary phosphine protected with a borane to undergo oxidative coupling without oxidation of the P-moiety is demonstrated for the first time. The reaction, which proceeds at room temperature, is applicable to the preparation of enantioenriched and structurally complex alkynylphosphine-boranes.