Synthetic Hydrogenases: Incorporation of an Iron Carbonyl Thiolate into a Designed Peptide

详细信息    查看全文

• 作者：Anne K. Jones ; Bruce R. Lichtenstein ; Arnab Dutta ; Gwyneth Gordon ; P. Leslie Dutton
• 刊名：Journal of the American Chemical Society
• 出版年：2007
• 出版时间：December 5, 2007
• 年：2007
• 卷：129
• 期：48
• 页码：14844 - 14845
• 全文大小：35K
• 年卷期：v.129,no.48(December 5, 2007)
• ISSN：1520-5126

文摘

[FeFe] hydrogenases catalyze reversible hydrogen oxidation at an unusual organometallic active site. Neither enzymatic studies nor synthesis of small molecule models has managed to elucidate the mechanisms of these enzymes. In this paper, we demonstrate the incorporation of an iron carbonyl thiolate mimic of the hydrogenase active site into a de novo artificial peptide, creating the first peptide-based model system for hydrogenases.