Manufacture of High-Purity Meloxicam via Its Novel Potassium Salt Monohydrate

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• 作者：Tibor Mezei ; Norbert Mesterhzy ; Tibor Bak ; Mrta Porcs-Makkay ; Gyula Simig ; Balzs Volk
• 刊名：Organic Process Research & Development
• 出版年：2009
• 出版时间：May 15, 2009
• 年：2009
• 卷：13
• 期：3
• 页码：567-572
• 全文大小：131K
• 年卷期：v.13,no.3(May 15, 2009)
• ISSN：1520-586X

文摘

An improved procedure for the manufacture of 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (meloxicam) is described. The key intermediate of this protocol is the new potassium salt monohydrate of meloxicam, which makes possible the efficient removal of impurities, resulting in an environmentally friendly manufacturing process of the high-purity (>99.90%) drug substance.