Desorption Atmospheric Pressure Photoionization

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• 作者：Markus Haapala ; Jaroslav Pó ; l ; Ville Saarela ; Ville Arvola ; Tapio Kotiaho ; Raimo A. Ketola ; Sami Franssila ; Tiina J. Kauppila ; Risto Kostiainen
• 刊名：Analytical Chemistry
• 出版年：2007
• 出版时间：October 15, 2007
• 年：2007
• 卷：79
• 期：20
• 页码：7867 - 7872
• 全文大小：337K
• 年卷期：v.79,no.20(October 15, 2007)
• ISSN：1520-6882

文摘

An ambient ionization technique for mass spectrometry,desorption atmospheric pressure photoionization (DAPPI), is presented, and its application to the rapid analysisof compounds of various polarities on surfaces is demonstrated. The DAPPI technique relies on a heatednebulizer microchip delivering a heated jet of vaporizedsolvent, e.g., toluene, and a photoionization lamp emitting10-eV photons. The solvent jet is directed toward samplespots on a surface, causing the desorption of analytes fromthe surface. The photons emitted by the lamp ionize theanalytes, which are then directed into the mass spectrometer. The limits of detection obtained with DAPPI werein the range of 56-670 fmol. Also, the direct analysis ofpharmaceuticals from a tablet surface was successfullydemonstrated. A comparison of the performance of DAPPI with that of the popular desorption electrospray ionization method was done with four standard compounds.DAPPI was shown to be equally or more sensitive especially in the case of less polar analytes.